Mitochondrial-derived research peptide catalogued for metabolic-pathway studies.
- Dose
- 10 mg
- Batch
- 268003
MOTS-c
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) · MRWQEMGYIFYPRKLR
For research purposes only — This compound is not FDA approved. All data presented is from clinical trials for educational reference.
Mitochondrial-derived research peptide catalogued for metabolic-pathway studies.
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- Lab
- Freedom Diagnostics
- Purity
- 99.22%
- Methods
- HPLC-UV · LC-MS
- Tested
- Sep 25, 2026
For laboratory research use only. Not for human consumption.
Technical specifications
- Type
- Peptide
- Scientific name
- MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c)
- Amino acids
- 16
- Sequence
- MRWQEMGYIFYPRKLR
- Molecular weight
- 2174.6 g/mol
- Formula
- C101H152N28O22S2
- CAS
- 1627580-64-6
- Origin
- Encoded by a short open reading frame within the mitochondrial 12S rRNA gene (MT-RNR1, mtDNA); UniProt A0A0C5B5G6 (MOTSC_HUMAN), 16 aa.
- Lyophilized (powder)
- -20°C, desiccated and protected from light · stable long-term (standard handling for lyophilized research peptides)
- Reconstituted
- 2-8°C in sterile bacteriostatic or distilled water · use within ~30 days; aliquot and avoid repeated freeze-thaw cycles
- Room temperature
- Lyophilized powder tolerates brief ambient excursions such as shipping (days), but is not intended for room-temperature storage; peptide in solution degrades within hours to days at room temperature and should be returned to refrigeration immediately after use.
Peer-reviewed research
Published research and registered trials involving this compound. Provided for educational reference only — none of it is a claim about this product.
- Cell MetabolismThe mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceLee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P2015DOI: 10.1016/j.cmet.2015.02.009PMID: 25738459
- Cell MetabolismThe Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic StressKim KH, Son JM, Benayoun BA, Lee C2018DOI: 10.1016/j.cmet.2018.06.008PMID: 29983246
- Nature CommunicationsMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasisReynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C2021DOI: 10.1038/s41467-020-20790-0PMID: 33473109
- Physiological ReportsThe mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivityKim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P2019DOI: 10.14814/phy2.14171PMID: 31293078
- Frontiers in EndocrinologyMitochondrial-Derived Peptides Are Down Regulated in Diabetes SubjectsRamanjaneya M, Bettahi I, Jerobin J, Chandra P, Abi Khalil C, Skarulis M, Atkin SL, Abou-Samra AB2019DOI: 10.3389/fendo.2019.00331PMID: 31214116
- Aging CellThe mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, Lucia A, Hirose N2015DOI: 10.1111/acel.12389PMID: 26289118
- ClinicalTrials.gov registry record (NCT03998514)A Phase 1a/1b Study of Safety, Tolerability, and Pharmacokinetics of CB4211 in Healthy Non-obese Subjects and Subjects With Nonalcoholic Fatty Liver DiseaseCohBar, Inc. (sponsor)2018
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