Small-molecule research compound catalogued for metabolic-pathway studies.
- Dose
- 50 mg
- Batch
- 268023
5-Amino-1MQ
5-Amino-1-methylquinolinium (IUPAC: 1-methylquinolin-1-ium-5-amine); commonly supplied as the iodide salt
For research purposes only — This compound is not FDA approved. All data presented is from clinical trials for educational reference.
Small-molecule research compound catalogued for metabolic-pathway studies.
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- Lab
- Janoshik Analytical
- Methods
- HPLC · LC-MS
For laboratory research use only. Not for human consumption.
Technical specifications
- Type
- Small molecule
- Scientific name
- 5-Amino-1-methylquinolinium (IUPAC: 1-methylquinolin-1-ium-5-amine); commonly supplied as the iodide salt
- Molecular weight
- 159.21 g/mol (free cation); 286.11 g/mol as the iodide salt
- Formula
- C10H11N2+ (cation); C10H11IN2 (iodide salt)
- CAS
- 685079-15-6 (cation); 42464-96-0 (iodide salt)
- Origin
- Synthetic quaternary N-methylquinolinium — a substrate-site-directed inhibitor of nicotinamide N-methyltransferase (NNMT); not a peptide and not gene-encoded. Identified within the methylquinolinium NNMT-inhibitor series reported in J Med Chem 2017 (PMID 28548833).
- Lyophilized (powder)
- -20°C, desiccated and protected from light · stable long-term as the dry powder/salt
- Reconstituted
- 2-8°C · use within 30 days; for longer holds aliquot and store at -20°C to avoid repeated freeze-thaw
- Room temperature
- Dry powder tolerates short ambient excursions in transit, but sustained room-temperature storage with humidity or light exposure risks caking of the hygroscopic salt and oxidation of the 5-amino group. Solutions should not be held at room temperature.
Peer-reviewed research
Published research and registered trials involving this compound. Provided for educational reference only — none of it is a claim about this product.
- Journal of Medicinal ChemistryStructure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-MethyltransferaseNeelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ2017DOI: 10.1021/acs.jmedchem.7b00389PMID: 28548833
- Biochemical PharmacologySelective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in miceNeelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ2018DOI: 10.1016/j.bcp.2017.11.007PMID: 29155147
- Biochemical PharmacologySmall molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscleNeelakantan H, Brightwell CR, Graber TG, Maroto R, Wang HL, McHardy SF, Papaconstantinou J, Fry CS, Watowich SJ2019DOI: 10.1016/j.bcp.2019.02.008PMID: 30753815
- Journal of Obstetrics and GynaecologySmall molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cellsAkar S, Duran T, Azzawri AA, Kocak N, Celik C, Yildirim HI2021DOI: 10.1080/01443615.2020.1854696PMID: 33645410
- Scientific ReportsCombined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese miceSampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, Watowich SJ2021DOI: 10.1038/s41598-021-85051-6PMID: 33707534
- Scientific ReportsReduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO miceDimet-Wiley A, Wu Q, Wiley JT, Eswar A, Neelakantan H, Savidge T, Watowich S2022DOI: 10.1038/s41598-021-03670-5PMID: 35013352
- Scientific ReportsNicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged miceDimet-Wiley AL, Latham CM, Brightwell CR, Neelakantan H, Keeble AR, Thomas NT, Noehren H, Fry CS, Watowich SJ2024DOI: 10.1038/s41598-024-66034-9PMID: 38969654
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